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secobarbital will lower the level or effect of fedratinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Effect of coadministering a powerful CYP3A4 inducer with fedratinib has not been researched.secobarbital will lower the level or effect of conjugated estrogens, vaginal by influencing hepatic/inte